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1

Parasite-specific trypanothione reductase as a drug target molecule

R. Luise Krauth-Siegel, Oliver Inhoff

Journal:

Parasitology Research

Year:

2003

Language:

english

File:

PDF, 326 KB

english, 2003

2

Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei

Schirmeister, Tanja, Schmitz, Janina, Jung, Sascha, Schmenger, Torsten, Luise Krauth-Siegel, R., Gütschow, Michael

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 666 KB

english, 2016

3

Crystal structure of theTrypanosoma cruzi trypanothione reductase·mepacrine complex

Jacoby, Elke M., Schlichting, Ilme, Lantwin, Christina B., Kabsch, Wolfgang, Krauth-Siegel, R. Luise

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1996

Language:

english

File:

PDF, 816 KB

english, 1996

4

Ungewöhnlich verbrückte Wolframkomplexe mit W(ER)2 W(ER)3 W-Gerüst (E = S oder Se; R = C2H5, n-C4H9 bzw. C6H5)

Luise R. Krauth-Siegel, Luis E. R. Krauth-Siegel, Wolfgang Schulze, Manfred L. Ziegler

Journal:

Angewandte Chemie

Year:

1980

Language:

german

File:

PDF, 232 KB

german, 1980

5

Inhibitoren von Disulfid-Reduktasen als Chemotherapeutica – Design von Wirkstoffen gegen die Chagas-Krankheit und gegen die Malaria

Prof. Dr. R. Heiner Schirmer, Dr. Joachim G. Müller, Priv.-Doz. Dr. R. Luise Krauth-Siegel

Journal:

Angewandte Chemie

Year:

1995

Language:

german

File:

PDF, 1.66 MB

german, 1995

6

Dithiolproteine als Hüter des intrazellulären Redoxmilieus bei Parasiten: alte und neue Wirkstoff-Targets bei Trypanosomiasis und Malaria

R. Luise Krauth-Siegel, Holger Bauer, R. Heiner Schirmer

Journal:

Angewandte Chemie

Year:

2005

Language:

german

File:

PDF, 866 KB

german, 2005

7

Unusually Bridged Tungsten Complexes with W(ER)2W(ER)3W Skeleton (ES or Se; R C2H5, n-C4H9, or C6H5)

Dipl.-Chem. Luise R. Krauth-Siegel, Dipl.-Chem. Wolfgang Schulze, Prof. Dr. Manfred L. Ziegler

Journal:

Angewandte Chemie International Edition

Year:

1980

Language:

english

File:

PDF, 241 KB

english, 1980

8

Disulfide-Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

Prof. Dr. R. Heiner Schirmer, Dr. Joachim G. Müller, Priv.-Doz. R. Luise Krauth-Siegel

Journal:

Angewandte Chemie International Edition

Year:

1995

Language:

english

File:

PDF, 1.68 MB

english, 1995

9

Dithiol Proteins as Guardians of the Intracellular Redox Milieu in Parasites: Old and New Drug Targets in Trypanosomes and Malaria-Causing Plasmodia

R. Luise Krauth-Siegel, Holger Bauer, R. Heiner Schirmer

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 1.47 MB

english, 2005

10

Pentafluorosulfanyl as a Novel Building Block for Enzyme Inhibitors: Trypanothione Reductase Inhibition and Antiprotozoal Activities of Diarylamines

Bernhard Stump, Christian Eberle, W. Bernd Schweizer, Marcel Kaiser, Reto Brun, R. Luise Krauth-Siegel, Dieter Lentz, François Diederich

Journal:

Year:

2009

Language:

english

File:

PDF, 516 KB

english, 2009

11

Dithiol Proteins as Guardians of the Intracellular Redox Milieu in Parasites: Old and New Drug Targets in Trypanosomes and Malaria-Causing Plasmodia

R. Luise Krauth-Siegel, Holger Bauer, R. Heiner Schirmer

Journal:

Year:

2005

File:

PDF, 8 KB

2005

12

Betraying the Parasite’s Redox System: Diaryl Sulfide-Based Inhibitors of Trypanothione Reductase: Subversive Substrates and Antitrypanosomal Properties

Bernhard Stump, Marcel Kaiser, Reto Brun, R. Luise Krauth-Siegel, François Diederich

Journal:

Year:

2007

Language:

english

File:

PDF, 263 KB

english, 2007

13

Unsaturated Mannich Bases Active Against Multidrug-Resistant Trypanosoma brucei brucei Strains

I. Nicole Wenzel, Pui E. Wong, Louis Maes, Thomas J. J. Müller, R. Luise Krauth-Siegel, Michael P. Barrett, Elisabeth Davioud-Charvet

Journal:

Year:

2009

Language:

english

File:

PDF, 432 KB

english, 2009

14

Redox Signaling and Regulation in Biology and Medicine. Edited by Claus Jacob and Paul G. Winyard.

R. Luise Krauth-Siegel

Journal:

Year:

2009

Language:

english

File:

PDF, 135 KB

english, 2009

15

Synthesis, Inhibition Potency, Binding Mode, and Antiprotozoal Activities of Fluorescent Inhibitors of Trypanothione Reductase Based on Mepacrine-Conjugated Diaryl Sulfide Scaffolds

Christian Eberle, Johannes A. Burkhard, Bernhard Stump, Marcel Kaiser, Reto Brun, R. Luise Krauth-Siegel, François Diederich

Journal:

Year:

2009

Language:

english

File:

PDF, 555 KB

english, 2009

16

Inside Cover: Synthesis, Inhibition Potency, Binding Mode, and Antiprotozoal Activities of Fluorescent Inhibitors of Trypanothione Reductase Based on Mepacrine-Conjugated Diaryl Sulfide Scaffolds (ChemMedChem 12/2009)

Christian Eberle, Johannes A. Burkhard, Bernhard Stump, Marcel Kaiser, Reto Brun, R. Luise Krauth-Siegel, François Diederich

Journal:

Year:

2009

File:

PDF, 467 KB

2009

17

Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities

Christian Eberle, Birgit Sophia Lauber, Daniel Fankhauser, Marcel Kaiser, Prof. Dr. Reto Brun, Prof. Dr. R. Luise Krauth-Siegel, Prof. Dr. François Diederich

Journal:

Year:

2011

Language:

english

File:

PDF, 535 KB

english, 2011

18

Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase

Andrea Cavalli, Federica Lizzi, Salvatore Bongarzone, Reto Brun, R. Luise Krauth-Siegel, Maria Laura Bolognesi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 362 KB

english, 2009

19

Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors

Carlos H. Faerman, Savvas N. Savvides, Corey Strickland, Mark A. Breidenbach, James A. Ponasik, Bruce Ganem, Daniel Ripoll, R. Luise Krauth-Siegel, P. Andrew Karplus

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 634 KB

english, 1996

20

Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei

Sanjay K. Shahi, R. Luise Krauth-Siegel, Christine E. Clayton

Journal:

Molecular Microbiology

Year:

2002

Language:

english

File:

PDF, 231 KB

english, 2002

21

The Structure of Trypanosoma cruzitrypanothione Reductase in the Oxidized and NADPH Reduced State

Christina B. Lantwin, Ilme Schlichting, Wolfgang Kabsch, Emil F. Pai, R. Luise Krauth-Siegel

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1994

Language:

english

File:

PDF, 1.10 MB

english, 1994

22

Biological Activities of Xanthatin from Xanthium strumarium Leaves

Endalkachew Nibret, Mahamoud Youns, R. Luise Krauth-Siegel, Michael Wink

Journal:

Phytotherapy Research

Year:

2011

Language:

english

File:

PDF, 230 KB

english, 2011

23

Die Molekül- und Kristallstrukturen von (CO)4 W(μ-S-t-C4H9)2W(CO)4, η7-C7H7W(μ-SC6H4CH3)3W(CO)3 und η7-C7H7W(μ-S-n-C4H9)3W(CO)(μ-S-n-C4H9)2W(CO)4

Marita Hohmann, Luise Krauth-Siegel, Dr. K. Weidenhammer, Wolfgang Schulze, Prof. Dr. Manfred L. Ziegler

Journal:

Zeitschrift für anorganische und allgemeine Chemie

Year:

1981

File:

PDF, 714 KB

1981

24

1H,13C, and15N assignment of the oxidized and reduced forms ofT. bruceiglutathione peroxidase-type tryparedoxin peroxidase

Johannes Melchers, Luise Krauth-Siegel, Claudia Muhle-Goll

Journal:

Biomolecular NMR Assignments

Year:

2008

Language:

english

File:

PDF, 374 KB

english, 2008

25

Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei

Angela Roldán, Marcelo A. Comini, Martina Crispo, R. Luise Krauth-Siegel

Journal:

Molecular Microbiology

Year:

2011

Language:

english

File:

PDF, 1.19 MB

english, 2011

26

Irreversible Inactivation of Trypanothione Reductase by Unsaturated Mannich Bases: A Divinyl Ketone as Key Intermediate

Lee, Brittany, Bauer, Holger, Melchers, Johannes, Ruppert, Thomas, Rattray, Lauren, Yardley, Vanessa, Davioud-Charvet, Elisabeth, Krauth-Siegel, R. Luise

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 238 KB

english, 2005

27

Reduction of dehydroascorbate by trypanothione

R.Luise Krauth-Siegel, Heike Lüdemann

Journal:

Molecular and Biochemical Parasitology

Year:

1996

Language:

english

File:

PDF, 542 KB

english, 1996

28

The conserved Cys76 plays a crucial role for the conformation of reduced glutathione peroxidase-type tryparedoxin peroxidase

Claudia Muhle-Goll, Florian Füller, Anne S. Ulrich, R. Luise Krauth-Siegel

Journal:

Year:

2010

Language:

english

File:

PDF, 655 KB

english, 2010

29

A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage

Michael Diechtierow, R. Luise Krauth-Siegel

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 1.38 MB

english, 2011

30

Preparative enzymatic synthesis of trypanothione and trypanothione analogues

Marcelo A. Comini, Natalie Dirdjaja, Mariel Kaschel, R. Luise Krauth-Siegel

Journal:

International Journal for Parasitology

Year:

2009

Language:

english

File:

PDF, 216 KB

english, 2009

31

Cytotoxic interactions of methylene blue with trypanosomatid-specific disulfide reductases and their dithiol products

Kathrin Buchholz, Marcelo A. Comini, Dirk Wissenbach, R. Heiner Schirmer, R. Luise Krauth-Siegel, Stephan Gromer

Journal:

Molecular and Biochemical Parasitology

Year:

2008

Language:

english

File:

PDF, 262 KB

english, 2008

32

Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes

Alexandra Wendler, Thorsten Irsch, Naila Rabbani, Paul J. Thornalley, R. Luise Krauth-Siegel

Journal:

Molecular and Biochemical Parasitology

Year:

2009

Language:

english

File:

PDF, 370 KB

english, 2009

33

Enzymatic reduction studies of nitroheterocycles

Cécile Viodé, Nadir Bettache, Narimantas Cenas, R.Luise Krauth-Siegel, Gérard Chauvière, Norbert Bakalara, Jacques Périé

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 319 KB

english, 1999

34

Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase

Klaus Blumenstiel, Ralf Schöneck, Vanessa Yardley, Simon L. Croft, R.Luise Krauth-Siegel

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 318 KB

english, 1999

35

Growth inhibition of bloodstream forms of Trypanosoma brucei by the iron chelator deferoxamine

Tanja Breidbach, Stefan Scory, R.Luise Krauth-Siegel, Dietmar Steverding

Journal:

International Journal for Parasitology

Year:

2002

Language:

english

File:

PDF, 217 KB

english, 2002

36

Silencing of the thioredoxin gene in Trypanosoma brucei brucei

Armin Schmidt, Christine E. Clayton, R.Luise Krauth-Siegel

Journal:

Molecular and Biochemical Parasitology

Year:

2002

Language:

english

File:

PDF, 171 KB

english, 2002

37

Thiol-based redox metabolism of protozoan parasites

Sylke Müller, Eva Liebau, Rolf D. Walter, R.Luise Krauth-Siegel

Journal:

Trends in Parasitology

Year:

2003

Language:

english

File:

PDF, 396 KB

english, 2003

38

Glutamate dehydrogenase, the marker protein of Plasmodium falciparum : Cloning, expression and characterization of the malarial enzyme

Jan T. Wagner, Heike Lüdemann, Petra M. Färber, Friedrich Lottspeich, R. Luise Krauth-Siegel

Journal:

Year:

1998

Language:

english

File:

PDF, 253 KB

english, 1998

39

Glutathione Reductase from Human Erythrocytes : Amino-Acid Sequence of the Structurally Known FAD-Binding Domain

Renate UNTUCHT-GRAU, R. Heiner SCHIRMER, Ilse SCHIRMER, R. Luise KRAUTH-SIEGEL

Journal:

Year:

1981

Language:

english

File:

PDF, 1.08 MB

english, 1981

40

Glutathione Reductase from Human Erythrocytes : The Sequences of the NADPH Domain and of the Interface Domain

R. Luise KRAUTH-SIEGEL, Mansoor SALEH, Renate UNTUCHT-GRAU, R. Heiner SCHIRMER, Rosi BLATTERSPIEL, Emile SCHILTZ

Journal:

Year:

1982

Language:

english

File:

PDF, 841 KB

english, 1982

41

Interaction of a glutathione S-conjugate with glutathione reductase Kinetic and X-ray crystallographic studies

Manfred BILZER, R. Luise KRAUTH-SIEGEL, R. Heiner SCHIRMER, Theo P. M. AKERBOOM, Helmut SIES, Georg E. SCHULZ

Journal:

Year:

1984

Language:

english

File:

PDF, 578 KB

english, 1984

42

FAD analogues as prosthetic groups of human glutathione reductase : Properties of the modified enzyme species and comparisons with the active site structure

R. Luise KRAUTH-SIEGEL, R. Heiner SCHIRMER, Sandro GHISLA

Journal:

Year:

1985

Language:

english

File:

PDF, 1015 KB

english, 1985

43

Mitochondrial adenylate kinase (AK2) from bovine heart : The complete primary structure

Rainer FRANK, Marcus TROSIN, Alfredo G. TOMASSELLI, Lafayette NODA, R. Luise KRAUTH-SIEGEL, R. Heiner SCHIRMER

Journal:

Year:

1986

Language:

english

File:

PDF, 579 KB

english, 1986

44

Trypanothione reductase from Trypanosoma cruzi : Purification and characterization of the crystalline enzyme

R. Luise KRAUTH-SIEGEL, Burkhard ENDERS, Graeme B. HENDERSON, Alan H. FAIRLAMB, R. Heiner SCHIRMER

Journal:

Year:

1987

Language:

english

File:

PDF, 673 KB

english, 1987

45

Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea : A crystallographic analysis

P. Andrew KARPLUS, R. Luise KRAUTH-SIEGEL, R. Heiner SCHIRMER, Georg E. SCHULZ

Journal:

Year:

1988

Language:

english

File:

PDF, 592 KB

english, 1988

46

Trypanothione reductase from Trypanosoma cruzi : Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds

Maria C. JOCKERS-SCHERÜBL, R. Heiner SCHIRMER, R. Luise KRAUTH-SIEGEL

Journal:

Year:

1989

Language:

english

File:

PDF, 583 KB

english, 1989

47

Purification and characterization of lipoamide dehydrogenase from Trypanosoma cruzi

Helmut LOHRER, R. Luise KRAUTH-SIEGEL

Journal:

Year:

1990

Language:

english

File:

PDF, 706 KB

english, 1990

48

Glutathione Reductase and Glutamate Dehydrogenase of Plasmodium Falciparum, The Causative Agent of Tropical Malaria

R. Luise Krauth-Siegel, Joachim G. Müller, Friedrich Lottspeich, R. Heiner Schirmer

Journal:

Year:

1996

Language:

english

File:

PDF, 1.01 MB

english, 1996

49

Ajoene Is an Inhibitor and Subversive Substrate of Human Glutathione Reductase and Trypanosoma cruzi Trypanothione Reductase: Crystallographic, Kinetic, and Spectroscopic Studies

Gallwitz, Helge, Bonse, Susanne, Martinez-Cruz, Alfonso, Schlichting, Ilme, Schumacher, Karin, Krauth-Siegel, R. Luise

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 140 KB

english, 1999

50

2- and 3-Substituted 1,4-Naphthoquinone Derivatives as Subversive Substrates of Trypanothione Reductase and Lipoamide Dehydrogenase from Trypanosoma cruzi: Synthesis and Correlation between Redox Cycling Activities and in Vitro Cytotoxicity

Salmon-Chemin, Laurence, Buisine, Eric, Yardley, Vanessa, Kohler, Sven, Debreu, Marie-Ange, Landry, Valérie, Sergheraert, Christian, Croft, Simon L., Krauth-Siegel, R. Luise, Davioud-Charvet, Elisabet

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 468 KB

english, 2001